physicians
Dr. Michael S. Alvarez is a nationally recognized Pulmonary and Critical Care specialist with extensive experience in clinical care, medical leadership, and translational research. As a physician executive, educator, and investigator, he has dedicated his career to advancing the diagnosis and treatment of complex respiratory diseases while improving standards of patient care across multiple healthcare settings.
Dr. Alvarez has served as Principal Investigator and Sub-Investigator in clinical trials involving asthma, COPD, chronic cough, interstitial lung disease, and emerging respiratory therapies. His expertise in advanced pulmonary diagnostics, critical care medicine, and clinical research provides valuable insight into the development of innovative treatments and improved outcomes for patients with pulmonary disease.
Areas of Expertise
Pulmonary & Critical Care Medicine | Asthma & Severe Asthma | Chronic Obstructive Pulmonary Disease (COPD) |Interstitial Lung Disease (ILD) | Chronic Cough | Advanced Bronchoscopy & EBUS |Respiratory Clinical Trials | Medical Leadership
Michael S. Álvarez
DO | MPH | FCCP
Pulmonary & Critical Care Medicine Clinical Research Investigator
Experienced physicians dedicated to advancing clinical research across multiple therapeutic areas.
MEDICAL LEADERSHIP
& RESEARCH EXPERTISE
Dr. Stephanie Delgado is a board-certified Family Medicine physician and Principal Investigator with experience in Phase II–IV clinical trials. Her clinical background includes primary care, chronic disease management, preventive medicine, and patient-centered care across diverse populations. She has participated in multiple industry-sponsored studies and is experienced in participant evaluation, safety oversight, protocol compliance, and clinical trial execution.
Areas of Expertise
Family Medicine | Primary Care | Comprehensive Physical Examinations | Chronic Disease Management | Phase II–IV Clinical Trials | Safety & Tolerability Assessments | Protocol Compliance | Clinical Research Operations | Preventive Medicine | Participant Recruitment & Retention
Stephanie M. Delgado
MD
Principal Investigator | Family Medicine Physician
With decades of experience in family medicine and clinical research, Dr. Pier Derek Frank brings a wealth of medical expertise to Crown Research. Trained at institutions affiliated with Yale University and the University of South Florida, he has dedicated his career to delivering exceptional patient care while supporting the development of innovative therapies through clinical research.
Dr. Frank has extensive experience managing chronic and complex medical conditions and has served as both Principal Investigator and Sub-Investigator in studies involving diabetes, respiratory diseases, nephrology, gastroenterology, infectious diseases, and cardiovascular health. His patient-focused approach, clinical excellence, and commitment to research quality contribute significantly to the mission of Crown Research.
Areas of Expertise
Family Medicine | Diabetes | Obesity Management | Hypertension | Respiratory Diseases | Clinical Research
Pier D. Frank
MD
Family Medicine | Clinical Research Investigator
Dr. Mallay is a distinguished Rheumatologist whose career spans clinical care, medical education, scientific research, and professional leadership. With extensive experience managing autoimmune and inflammatory disorders, she is dedicated to delivering evidence-based, patient-centered care while contributing to the advancement of innovative treatment options through clinical research.
Beyond her clinical practice, Dr. Mallay has held faculty and mentorship roles, authored scientific publications, presented educational lectures, and actively participated in national rheumatology organizations. Her commitment to advancing medical knowledge and fostering excellence in patient care reflects the core values of Crown Research and its mission to improve lives through research.
Areas of Expertise
Rheumatoid Arthritis (RA) | Osteoarthritis | Autoimmune Diseases | Inflammatory Arthritis | Connective Tissue Disorders | Musculoskeletal Ultrasound | Internal Medicine | Clinical Research | Patient Education & Disease Management
Rubaiya Y. Mallay
DO
Rheumatology | Clinical Research Investigator
Dr. Ernesto J. Millán is a board-certified Child Neurologist and Clinical Neurophysiologist with extensive experience in pediatric neurology, epilepsy management, EEG interpretation, and neurodevelopmental disorders. Following his medical training in Venezuela, he completed pediatric residency training at Albert Einstein College of Medicine and a Child Neurology residency at Vanderbilt University Medical Center, followed by fellowship training in Clinical Neurophysiology (EEG/EMG and Epilepsy).
Throughout his career, Dr. Millán has provided specialized neurological care to children and adolescents while contributing to clinical research focused on epilepsy and neurological disorders. His experience as Principal Investigator and Sub-Investigator includes multiple clinical studies evaluating novel therapies for epilepsy and seizure disorders. Dr. Millán combines clinical excellence, research expertise, and a patient-centered approach to advance innovative treatments for pediatric and neurological populations.
Areas of Expertise
Pediatric Neurology | Epilepsy & Seizure Disorders | Clinical Neurophysiology (EEG/EMG) | Neurodevelopmental Disorders | Neurological Clinical Research | Pediatric Neurological Care | Clinical Trial Leadership | Bilingual Patient Care (English & Spanish)
Ernesto J. Millán
MD
Pediatric Neurology | Epilepsy | Clinical Neurophysiology | Principal Investigator
Rigoberto Núñez is a Family Nurse Practitioner and Clinical Research Sub-Investigator with over 20 years of healthcare experience in acute care, internal medicine, chronic disease management, and clinical research. His background includes hospital-based nursing, advanced patient assessment, safety monitoring, and support of clinical trial operations. As a Sub-Investigator, he contributes to participant evaluation, protocol compliance, and study execution while ensuring high-quality patient care.
Areas of Expertise
Family Medicine | Comprehensive Physical Examinations | IV Therapy & PICC Line Management | Cardiovascular Monitoring | Internal Medicine | Safety Assessments & Adverse Event Monitoring | Clinical Research Operations | Patient Education & Chronic Disease Management | Bilingual Patient Care (English & Spanish)
Rigoberto Núñez
MSN | APRN | FNP-C
Family Nurse Practitioner | Sub-Investigator
Experienced Investigators | Dedicated Research Staff | On-Site laboratory | Investigational Product Management | Participant-Centered Care
MEDICAL LEADERSHIP
& RESEARCH EXPERTISE
Dr. Jack Parrino is a highly experienced Allergy and Immunology specialist whose career spans decades of clinical practice and clinical research. Board-certified in both Internal Medicine and Allergy & Immunology, he has dedicated his professional life to the diagnosis, treatment, and prevention of allergic, immunologic, and respiratory diseases.
In addition to his longstanding private practice experience, Dr. Parrino has participated in numerous clinical trials as both Principal Investigator and Sub-Investigator, contributing to the development of innovative therapies for asthma, COPD, allergic rhinitis, and related respiratory conditions. His commitment to evidence-based medicine, research excellence, and compassionate patient care supports Crown Research’s mission of bringing new treatment opportunities to the communities it serves.
Areas of Expertise
Allergy & Immunology | Asthma & Severe Asthma | Allergic Rhinitis | COPD | Respiratory Clinical Trials | Immunologic Disorders | Internal Medicine | Clinical Research
Jack Parrino
MD
Allergy, Asthma & Immunology | Clinical Research Investigator
Dr. Rafael L. M. Rodríguez is a board-certified Neurologist and Clinical Neurophysiologist with more than three decades of experience in the diagnosis and management of neurological disorders. Following his Internal Medicine training at the University of Louisville and Neurology residency at the University of Maryland, Dr. Rodríguez established a long-standing clinical practice in Tampa, Florida, focused on epilepsy, neurophysiology, multiple sclerosis, movement disorders, and general neurology.
Throughout his distinguished career, he has served as investigator and sub-investigator in multiple neurological clinical trials, contributed to peer-reviewed scientific publications, and held leadership positions within regional and national medical organizations. His expertise spans advanced EEG interpretation, epilepsy management, neurodegenerative diseases, and neurological clinical research.
Areas of Expertise
General Neurology | Epilepsy & Seizure Disorders | Clinical Neurophysiology (EEG) | Multiple Sclerosis | Movement Disorders & Parkinson’s Disease | Neurological Clinical Research | Medical Education & Physician Training | Bilingual Patient Care (English & Spanish)
Rafael L. M. Rodríguez
MD
Neurology | Epilepsy | Clinical Neurophysiology | Multiple Sclerosis | Principal Investigator
Dr. Rafael Moisés Rodríguez is a highly skilled Neurologist and Clinical Neurophysiology specialist dedicated to advancing neurological care through clinical practice, education, and research. With advanced training in neurology and neurophysiology, he has extensive experience evaluating and treating a broad spectrum of neurological disorders, including epilepsy, neuromuscular diseases, cognitive conditions, and disorders of the central and peripheral nervous systems.
In addition to his clinical leadership roles, Dr. Rodríguez has contributed to scientific publications, academic presentations, and professional medical organizations. His commitment to evidence-based medicine, innovation, and patient-centered care supports Crown Research’s mission to bring new treatment opportunities to individuals affected by neurological disease.
Areas of Expertise
Neurology | Clinical Neurophysiology | Epilepsy & Seizure Disorders | Neuromuscular Disorders | EEG & Neurodiagnostic Testing | Cognitive Neurology | Neurodegenerative Diseases | Clinical Research
Rafael Moisés Rodríguez
MD
Neurology & Clinical Neurophysiology | Clinical Research Investigator
Dr. Orlando L. Ruano is a board-certified Psychiatrist with extensive experience in clinical care, academic medicine, and clinical research. Throughout his distinguished career, he has held leadership positions within major healthcare institutions, served as a Medical Director, and contributed to the education and mentorship of future physicians through his faculty appointments at the University of South Florida.
In addition to his clinical practice, Dr. Ruano has participated as both Principal Investigator and Sub-Investigator in numerous clinical trials involving psychiatric, neurological, and neurodegenerative disorders, including post-traumatic stress disorder (PTSD), bipolar disorder, Alzheimer’s disease, migraine, epilepsy, Parkinson’s disease, and obsessive-compulsive disorder (OCD). His dedication to advancing innovative therapies and improving patient outcomes reflects the commitment to excellence that defines Crown Research.
Areas of Expertise
Psychiatry | Mood & Anxiety Disorders | Post-Traumatic Stress Disorder (PTSD) | Bipolar Disorder | Obsessive-Compulsive Disorder (OCD) | Alzheimer’s Disease & Cognitive Disorders | Neuropsychiatric Conditions | Clinical Research